Yu, Hong Ren: xin sheng er bai xie qiu dui shui dou bing du gan ran zhi yi chang mian yi fan ying

wen xian shang yi jing zhi dao xin sheng er you jiao cha de di yi xing fu zhu xi bao Th1 fan ying zhe ke yi shuo ming xin sheng er gan ran shui dou shi you jiao duo jiao yan zhong de bing fa zheng su zhu de di yi xing fu zhu xi bao mian yi fan ying dui yu zhi kang xu duo xi bao nei bing yuan ti ji bing du gan ran shi bi xu de ran er zai wo men yan jiu jie guo zhong wo men fa xian qi dai xie dan he xing bai xie qiu zai jie shou qia jie miao kang yuan ci ji hou ke yi chan sheng yu cheng ren zhou bian xie dan he xing bai xie qiu deng liang shen zhi geng da liang de bing zhong gan rao su dan que wu fa zai shui dou kang yuan ci ji xia chan sheng zu liang de bing zhong gan rao su zhe ge jie guo gao su wo men xin sheng er dan he qiu de di yi xing fu zhu xi bao fan ying wei bi yi ding bi cheng ren cha er shi yi ci ji kang yuan bu tong er you suo bu tong geng jin yi bu de yan jiu jie guo xian shi shui dou bing du kang yuan you dao ren lei mian yi xi bao chan sheng yu jia zhong gan rao su IFN xiang guan de di yi xing fu zhu T xi bao fan ying er fei di shi er jie bai su IL 12 yi lai xing di yi xing fu zhu xi bao fan ying xin sheng er kang yuan cheng xian xi bao zai shui dou bing du gan ran shi wu fa chan sheng zu liang de jia zhong gan rao su shi xin sheng er you bu zheng chang de di yi xing fu zhu T xi bao fan ying de zhu yin wei shi me xin sheng er dan he qiu bu neng chan sheng zu liang de jia zhong gan rao su ni wo men jin yi bu yan jiu fa xian yi zhi lei duo yang di jiu shou qi TLR9 de CpG ODN fen zi yi ji zi wai xian zhao she jiang shui dou bing du qu huo hua shi qi zhi zuo yong zai TLR9 du hui jian shao jia zhong gan rao su de chan sheng yin ci wo men zhi dao shui dou bing du gan ran hui tong shi tou guo TLR9 shou qi yi lai xing ji TLR9 shou qi fei yi lai xing xun hao lu jing you dao jia zhong gan rao su de chan sheng jin yi bu de shi yan zhong wo men ze fa xian NF kB yi ji qi ta xi bao nei de xun hao fen zi MAPKs he PKR dui yu jia zhong gan rao su de chan sheng du ban yan le hen zhong yao de jiao se